I went through this debate before choosing my sub last month. I went with a ported sub for two main reasons. One--for LFE content, the ported design (of the two I was considering: SVS PB-2000 and SVS SB-2000) performed better. Two--my room size is large enough to accommodate the higher output of the lower frequencies in the sub 40HZ range (though only just, as an Anti-mode 8033 has proven very useful at taming the 22hz peak that is a natural byproduct of my room).
I have run many types of music through the system since I've installed everything and I can detect no problems (classical--symphonic and small ensembles, jazz, big band, prog rock, classic rock, my daughter's "boy band stuff", bluegrass, a bit of electronica--Daft Punk, folk). It all sounds great, with clean, articulate bass.
I have heard cheapo ported subs that sound horrible with music but Mr. Griffon's answer explains why they sound bad.
In a music only system, in a small room (one day, my kids will become adults and I can set something like that up in one of their bedrooms, I plan to go with a 2.1 set up with a sealed sub and some nice stand mounts. But for a mixed use set up, especially in a large room like yours, go with a ported sub. There are a number of really nice ones out there.