Bob,
I agree with Scott's response insofar as multiple subwoofers will even out room response and aid in preventing nulls and areas of over attenuation.
That said, for some individuals, purchasing multiple subwoofers may not be a viable option and your room may not accommodate 2-4 subwoofers unless your room is large or you plan to go the in-wall route. One alternative may be tower speakers such Definitive Technology or Golden Ear Technology which incorporate well designed powered subwoofers. Consider purchasing an av receiver that incorporates Audyssey MultiEQ XT or XT 32 room correction as it may help even out bass response and minimize frequency anomalies. It's not a "cure all" but could help if you cannot afford to buy 2 or 4 stand alone subwoofers.
If you only want to purchase one subwoofer, consider one that has EQ built in to help minimize room modes. Consider Velodyne's DD+ series, JL Fathom, B&W DB1, or Paradigm subwoofers that include its PBK (Perfect Bass Kit).
Hope this helps