You mention an external amp. If you use a powered sub, you dont need that amp and can connect the receiver to the sub directly. Would that shorten the path between receiver and amp? Nothing wrong with a powered sub-in fact, some think its preferred, relieving the receiver/amp of having to drive it and getting cleaner, more powerful performance.
Secondly, if that cable path is still required, if your cable runs at 90 degrees to electrical wires, that will greatly reduce the chances of any EMI issues.