I have 3 remotes that I actively use. My Dish remote which can control some of my receiver, my receiver remote which can do most of the Dish remote (but my wife doesn't know all the buttons I assigned), and my PS3 remote which is Blu-Tooth and cannot control anything else, and nothing else can control the PS3!
I also have a laserdisc remote, a VCR remote, a remote for my component video switcher, and my TV remote, which except for the latter, all the rest are hidden away without any batteries.
The problem I find is that there is always some function on each remote that you actually use a lot, but is not mappable to the universal remote. Granted, I have not payed for something like a Logitech Harmony, let alone a touch screen which would be awesome. Do any universal remotes deal in Blu-Tooth? Cause that might be a tipping factor for me.